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Chemical Structure : Ponatinib
CAS No.: 943319-70-8
Catalog No.: PC-42862Not For Human Use, Lab Use Only.
Ponatinib (AP 24534) is a potent, orally active pan-inhibitor of BCR-ABL kinase with IC50 of 0.37 and 2.0 nM for ABL and mutant ABLT315I, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | $298 | In stock | |
| 250 mg | Get quote |
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Ponatinib (AP 24534) is a potent, orally active pan-inhibitor of BCR-ABL kinase with IC50 of 0.37 and 2.0 nM for ABL and mutant ABLT315I, respectively.
Ponatinib retains high potency against other ABL mutants Q252H, Y253F, M351T and H396P (IC50s<0.5 nM), also inhibits c-Src, Lyn, c-KIT, VEGFR2, FGFR1, PDGFRα (IC50s=0.2-5 nM).
Ponatinib inhibits the growth of cells expressing native or mutant BCR-ABL (IC50s=0.5–36 nM).
Ponatinib suppresses BCR-ABL(T315I)-driven tumor growth in mice, and completely abrogated resistance in cell-based mutagenesis screens.
| M.Wt | 532.5595 | |
| Formula | C29H27F3N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 50 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]- |
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1. Gozgit JM, et al. Mol Cancer Ther. 2011 Jun;10(6):1028-35.
2. Huang WS, et al. J Med Chem. 2010 Jun 24;53(12):4701-19.
3. O'Hare T, et al. Cancer Cell. 2009 Nov 6;16(5):401-12.
4. Gozgit JM, et al. Mol Cancer Ther. 2012 Mar;11(3):690-9.
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