Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-GPCR-Lysophospholipid Receptor-Ponesimod
Ponesimod

Chemical Structure : Ponesimod

CAS No.: 854107-55-4

Ponesimod (ACT-128800, ACT128800)

Catalog No.: PC-42656Not For Human Use, Lab Use Only.

Ponesimod (ACT-128800) is a potent, selective, orally active S1P1 receptor agonist with EC50 of 9.1 nM.

Packing Price Stock Quantity
10 mg $118 In stock
25 mg $188 In stock
50 mg $288 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ponesimod (ACT-128800) is a potent, selective, orally active S1P1 receptor agonist with EC50 of 9.1 nM.
Ponesimod (ACT-128800) shows weak activity on S1P3 (EC50=123 nM).
Ponesimod (ACT-128800) activates S1P1-mediated signal transduction with high potency (EC50 of 5.7 nM).
Ponesimod (ACT-128800) causes maximal reduction of circulating lymphocytes at a dose of 3 mg/kg.

Physicochemical Properties

M.Wt 460.9736
Formula C23H25ClN2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Thiazolidinone, 5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)-

References

1. Bolli MH, et al. J Med Chem. 2010 May 27;53(10):4198-211.

2. Piali L, et al. J Pharmacol Exp Ther. 2011 May;337(2):547-56.

3. Sobel K, et al. J Biol Chem. 2013 May 24;288(21):14839-51.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: