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Posaconazole hydrate

Chemical Structure : Posaconazole hydrate

CAS No.: 1198769-38-8

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Posaconazole hydrate (SCH-56592 hydrate)

Catalog No.: PC-45196Not For Human Use, Lab Use Only.

Posaconazole hydrate is a triazole antifungal agent that blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of methylated sterol precursors, more potent at inhibiting 14α-demethylase than itraconazole.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Posaconazole hydrate is a triazole antifungal agent that blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of methylated sterol precursors, more potent at inhibiting 14α-demethylase than itraconazole.

Physicochemical Properties

M.Wt 718.7927
Formula C37H44F2N8O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)- (hydrate)(1:1)

References

1. Benaim G, et al. J Med Chem. 2006 Feb 9;49(3):892-9.
2. Sabatelli F, et al. Antimicrob Agents Chemother. 2006 Jun;50(6):2009-15.

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