Chemical Structure : Poziotinib
CAS No.:
1092364-38-9
Poziotinib
(HM781-36B, NOV120101)
Catalog No. : PC-44668Not For Human Use, Lab Use Only.
Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for EGFRwt/HER-2/HER-4.
Packing Price Stock Quantity 5 mg $68 In stock 0 1 2 3 4 5 10 mg $98 In stock 0 1 2 3 4 5 25 mg $158 In stock 0 1 2 3 4 5 50 mg $248 In stock 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4466801
Biological Activity
Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for EGFRwt/HER-2/HER-4.
Physicochemical Properties
M.Wt
491.3423
Formula
C23H21Cl2FN4O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-Propen-1-one, 1-[4-[[4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-
References
1. Nam HJ, et al. Cancer Lett.
2. Cha MY, et al. Int J Cancer.
3. Kim HJ, et al. Anticancer Drugs.
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