Catalog No.: PC-61847Not For Human Use, Lab Use Only.
Pregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs).
Pregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs).
Pregabalin (CI-1008) prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons.
Pregabalin (CI-1008) does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.
Physicochemical Properties
M.Wt
159.23
Formula
C8H17NO2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(S)-3-(Aminomethyl)-5-methylhexanoic acid
References
1. Field MJ, et al. Br J Pharmacol. 1997 Aug;121(8):1513-22.
2. Field MJ, et al. J Pharmacol Exp Ther. 1997 Sep;282(3):1242-6.
