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Chemical Structure : Pregabalin
CAS No.: 148553-50-8
Catalog No.: PC-61847Not For Human Use, Lab Use Only.
Pregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs).
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Pregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs).
Pregabalin (CI-1008) prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons.
Pregabalin (CI-1008) does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.
| M.Wt | 159.23 | |
| Formula | C8H17NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-3-(Aminomethyl)-5-methylhexanoic acid |
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1. Field MJ, et al. Br J Pharmacol. 1997 Aug;121(8):1513-22.
2. Field MJ, et al. J Pharmacol Exp Ther. 1997 Sep;282(3):1242-6.
3. Eutamene H, et al. J Pharmacol Exp Ther. 2000 Oct;295(1):162-7.
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