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Pridopidine

Chemical Structure : Pridopidine

CAS No.: 346688-38-8

Pridopidine (ACR16;FR-310826;ASP-2314;Huntexil)

Catalog No.: PC-63432Not For Human Use, Lab Use Only.

Pridopidine (ACR16, FR-310826, ASP-2314, Huntexil) is a selective and potent Sigma-1 receptor agonist.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Pridopidine (ACR16, FR-310826, ASP-2314, Huntexil) is a selective and potent Sigma-1 receptor agonist.
Pridopidine also is a specific dopamine stabilizer without no partial agonism; shows robust dose-dependent striatal D2 occupancy with ED50 of 18.99 mg/kg s.c. in vivo, shows high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor side effects in rats.

Physicochemical Properties

M.Wt 281.414
Formula C15H23NO2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin

References

1. Natesan S, et al. J Pharmacol Exp Ther. 2006 Aug;318(2):810-8.

2. Nilsson M, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jul;28(4):677-85.

3. Seeman P, et al. Synapse. 2009 Oct;63(10):930-4.

4. Pettersson F, et al. J Med Chem. 2010 Mar 25;53(6):2510-20.

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