Pridopidine (ACR16, FR-310826, ASP-2314, Huntexil) is a selective and potent Sigma-1 receptor agonist.
Pridopidine also is a low affinity dopamine D2 receptor (D2R) antagonist and a specific dopamine stabilizer without no partial agonism.
Pridopidine shows robust dose-dependent striatal D2 occupancy with ED50 of 18.99 mg/kg s.c. in vivo, shows high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor side effects in rats.
