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Chemical Structure : Prodigiosin
CAS No.: 82-89-3
Catalog No.: PC-70223Not For Human Use, Lab Use Only.
Prodigiosin is a natural red pigment produced by numerous bacterial species, has exhibited promising anticancer activity.
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Prodigiosin is a natural red pigment produced by numerous bacterial species, has exhibited promising anticancer activity.
Prodigiosin a potent inhibitor of Wnt/β-catenin pathway by targeting multiple sites of this pathway, including LRP6, Dishevelled (DVL), and GSK3β.
Prodigiosin decreases phosphorylation of LRP6, DVL2, and GSK3β and suppressed β-catenin-stimulated Wnt target gene expression, including expression of cyclin D1, in breast cancer cells.
Prodigiosin slows tumor progression in vivo; restores p53 and activates p73 via regualtion of c-Jun in colorectal cancer stem cells.
| M.Wt | 323.432 | |
| Formula | C20H25N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-2,2'-bi-1H-pyrrole |
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1. Wang Z, et al. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13150-13155.
2. Prabhu VV, et al. Cancer Res. 2016 Apr 1;76(7):1989-99.
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