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Chemical Structure : Proxalutamide
Catalog No.: PC-70129Not For Human Use, Lab Use Only.
Proxalutamide (GT-0918) is a potent androgen receptor (AR) antagonist with ability to down regulate AR protein level in prostate cancer cells.
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Proxalutamide (GT-0918) is a potent androgen receptor (AR) antagonist with ability to down regulate AR protein level in prostate cancer cells.
Proxalutamide (GT-0918) is more potently inhibits androgen binding with AR's ligand binding domain than Bicalutamide (11.4-fold) and MDV3100 (3.5-fold) in biochemical assay.
Proxalutamide (GT-0918) demonstrates stronger potency to block AR function of gene transcription in CRPC cells.
Proxalutamide (GT-0918) demonstrates good anti-tumor efficacy among hormone sensitive, CRPC and AR+ breast cancer animal models.
| M.Wt | 517.5 | |
| Formula | C24H19F4N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Youzhi Tong, et al. DOI: 10.1158/1538-7445.AM2014-614 Published October 2014
2. Yang M, et al. Int J Pharm. 2014 Nov 20;475(1-2):97-109.
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