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Chemical Structure : Prucalopride
CAS No.: 179474-81-8
Catalog No.: PC-23280Not For Human Use, Lab Use Only.
Prucalopride (R-108512) is a potent, selective 5-HT4 receptor agonist with pKi of 8.6 and 8.1 for 5-HT4a and 5-HT4b, >290-fold higher affinity for 5-HT4 receptors than for other receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $138 | In stock | |
| 250 mg | $218 | In stock | |
| 1 g | Get quote |
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Prucalopride (R-108512) is a potent, selective 5-HT4 receptor agonist with pKi of 8.6 and 8.1 for 5-HT4a and 5-HT4b, >290-fold higher affinity for 5-HT4 receptors than for other receptors.
Prucalopride targets the impaired motility associated with chronic constipation, thus normalizing bowel movements.
Prucalopride induces contractions (pEC50=7.48) in the guinea-pig colon, demonstrates anti-cholinergic, anticholinesterase or nonspecific inhibitory activity and does not antagonise 5-HT2A, 5-HT2B and 5-HT3 receptors or motilin, CCK1 receptors.
| M.Wt | 367.87 | |
| Formula | C18H26ClN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide |
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1. Prins NH, et al. Br J Pharmacol. 1999 Jul;127(6):1431-7.
2. Poen AC, et al. Aliment Pharmacol Ther. 1999 Nov;13(11):1493-7.
3. Briejer MR, et al. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.
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