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Chemical Structure : Prucalopride succinate
CAS No.: 179474-85-2
Catalog No.: PC-43156Not For Human Use, Lab Use Only.
Prucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist with pKi of 8.6 and 8.1 for 5-HT4a and 5-HT4b, >290-fold higher affinity for 5-HT4 receptors than for other receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $78 | In stock | |
| 100 mg | $128 | In stock | |
| 250 mg | $198 | In stock | |
| 1 g | Get quote |
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Prucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist with pKi of 8.6 and 8.1 for 5-HT4a and 5-HT4b, >290-fold higher affinity for 5-HT4 receptors than for other receptors.
Prucalopride targets the impaired motility associated with chronic constipation, thus normalizing bowel movements.
Prucalopride induces contractions (pEC50=7.48) in the guinea-pig colon, demonstrates anti-cholinergic, anticholinesterase or nonspecific inhibitory activity and does not antagonise 5-HT2A, 5-HT2B and 5-HT3 receptors or motilin, CCK1 receptors.
| M.Wt | 485.9584 | |
| Formula | C22H32ClN3O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 36 mg/mL |
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| Chemical Name/SMILES |
Butanedioic acid, compd. with 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide (1:1) |
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1. Prins NH, et al. Br J Pharmacol. 1999 Jul;127(6):1431-7.
2. Poen AC, et al. Aliment Pharmacol Ther. 1999 Nov;13(11):1493-7.
3. Bouras EP, et al. Gut. 1999 May;44(5):682-6.
4. Briejer MR, et al. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.
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