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Psalmotoxin 1

Chemical Structure : Psalmotoxin 1

CAS No.: 316808-68-1

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Psalmotoxin 1 (PcTx1)

Catalog No.: PC-73334Not For Human Use, Lab Use Only.

Psalmotoxin 1 (PcTx1) is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker with IC50 of 0.9 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Psalmotoxin 1 (PcTx1) is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker with IC50 of 0.9 nM.
    Psalmotoxin 1 displays no effect at ASIC1b, ASIC2a, ASIC3, heteromeric ASIC channels, ENaC and KV2.1/2.2/4.2/4.3 channels expressed in oocytes at 100 nM.
    Psalmotoxin 1 exhibits potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents.

    Physicochemical Properties

    M.Wt 4689.41
    Formula C200H312N62O57S6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (Modifications: Disulfide bridges: 3-18, 10-23, 17-33)

    References

    1. Mazzuca M, et al. Nat Neurosci. 2007 Aug;10(8):943-5.

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