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Chemical Structure : Psora-4
Catalog No.: PC-62203Not For Human Use, Lab Use Only.
Psora-4 is a potent and selective Kv1.3 potassium channel blocker with EC50 of 3 nM.
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Psora-4 is a potent and selective Kv1.3 potassium channel blocker with EC50 of 3 nM.
Psora-4 shows 17- to 70-fold selectivity for Kv1.3 over closely related Kv1-family channels (Kv1.1, Kv1.2, Kv1.4, and Kv1.7) with the exception of Kv1.5 (EC50, 7.7 nM), and shows no effect on hERG, Kv3.1, the calcium-activated K+ channels (IKCa1, SK1-SK3, and BKCa), or the neuronal NaV1.2 channel.
Psora-4 selectively suppresses the proliferation of human and rat myelin-specific effector memory T cells with EC50 of 25 and 60 nM, respectively, without persistently suppressing peripheral blood naive and central memory T cells.
| M.Wt | 334.371 | |
| Formula | C21H18O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Vennekamp J, et al. Mol Pharmacol. 2004 Jun;65(6):1364-74.
2. Wulff H, et al. Nat Chem Biol. 2013 Aug;9(8):473-4.
3. Schmitz A, et al. Mol Pharmacol. 2005 Nov;68(5):1254-70.
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