PyP-1 | PDE10A inhibitor | Probechem Biochemicals

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Chemical Structure : PyP-1

PyP-1 (PyP1)

Catalog No.: PC-62700Not For Human Use, Lab Use Only.

PyP-1 is a potent, highly selective, and orally bioavailable PDE10A inhibitor with Ki of 0.23 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PyP-1 is a potent, highly selective, and orally bioavailable PDE10A inhibitor with Ki of 0.23 nM.
PyP-1 exhibits excellent pharmacokinetic and physicochemical properties, and a clean off-target profile.
PyP-1 displays in vivo preclinical target engagement and clean preclinical profile

Physicochemical Properties

M.Wt	375.436
Formula	C20H21N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(((1S,2S)-2-(pyridin-2-yl)cyclopropyl)methoxy)pyrazolo[1,5-a]pyrimidin-7-amine

References

1. Raheem IT, et al. Bioorg Med Chem Lett. 2016 Jan 1;26(1):126-32.

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PyP-1 (PyP1)

Biological Activity

Physicochemical Properties

References

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