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Chemical Structure : Pyrimidyn 7
Catalog No.: PC-62371Not For Human Use, Lab Use Only.
Pyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively, competitively inhibits both GTP and phospholipid interactions with dynamin.
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Pyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively, competitively inhibits both GTP and phospholipid interactions with dynamin.
Pyrimidyn 7 reversibly inhibits CME of both transferrin and EGF in a number of non-neuronal cell lines as well as inhibiting synaptic vesicle endocytosis (SVE) in nerve terminals.
Pyrimidyn 7 blocks clathrin-mediated endocytosis (CME).
| M.Wt | 363.59 | |
| Formula | C21H41N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. McGeachie AB, et al. ACS Chem Biol. 2013 Jul 19;8(7):1507-18.
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