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Pyrimidyn 7

Chemical Structure : Pyrimidyn 7

CAS No.: 1440126-94-2

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Pyrimidyn 7 (Pyrimidyn7)

Catalog No.: PC-62371Not For Human Use, Lab Use Only.

Pyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively, competitively inhibits both GTP and phospholipid interactions with dynamin.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Pyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively, competitively inhibits both GTP and phospholipid interactions with dynamin.
    Pyrimidyn 7 reversibly inhibits CME of both transferrin and EGF in a number of non-neuronal cell lines as well as inhibiting synaptic vesicle endocytosis (SVE) in nerve terminals.
    Pyrimidyn 7 blocks clathrin-mediated endocytosis (CME).

    Physicochemical Properties

    M.Wt 363.59
    Formula C21H41N5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N2-[2-(Dimethylamino)ethyl]-N4-dodecyl-6-methyl-2,4-pyrimidinediamine

    References

    1. McGeachie AB, et al. ACS Chem Biol. 2013 Jul 19;8(7):1507-18.

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