Catalog No.: PC-23949Not For Human Use, Lab Use Only.
Pyrrothiogatain is a small molecule inhibitor of transcription factor GATA3 with IC50 of 54.7 uM, inhibits the DNA-binding activity of GATA3 and other members of the GATA family.
Pyrrothiogatain is a small molecule inhibitor of transcription factor GATA3 with IC50 of 54.7 uM, inhibits the DNA-binding activity of GATA3 and other members of the GATA family. Pyrrothiogatain also inhibited the interaction between GATA3 and SOX4, suggesting that it interacts with the DNA-binding region of GATA3. Pyrrothiogatain significantly suppressed Th2 cell differentiation, without impairing Th1 cell differentiation, and inhibited the expression and production of Th2 cytokines. Pyrrothiogatain inhibited GATA3 DNA-binding to Th2 cytokine gene locus.
