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Pyrrothiogatain

Chemical Structure : Pyrrothiogatain

CAS No.: 477888-48-5

Pyrrothiogatain

Catalog No.: PC-23949Not For Human Use, Lab Use Only.

Pyrrothiogatain is a small molecule inhibitor of transcription factor GATA3 with IC50 of 54.7 uM, inhibits the DNA-binding activity of GATA3 and other members of the GATA family.

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Biological Activity

Pyrrothiogatain is a small molecule inhibitor of transcription factor GATA3 with IC50 of 54.7 uM, inhibits the DNA-binding activity of GATA3 and other members of the GATA family.
Pyrrothiogatain also inhibited the interaction between GATA3 and SOX4, suggesting that it interacts with the DNA-binding region of GATA3.
Pyrrothiogatain significantly suppressed Th2 cell differentiation, without impairing Th1 cell differentiation, and inhibited the expression and production of Th2 cytokines.
Pyrrothiogatain inhibited GATA3 DNA-binding to Th2 cytokine gene locus.

Physicochemical Properties

M.Wt 221.27
Formula C11H11NO2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(2,5-Dimethyl-1H-pyrrol-1-yl)thiophene-2-carboxylic acid

References

1. Nomura S, et al. Sci Rep. 2019 Nov 22;9(1):17335.

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