Catalog No.: PC-60384Not For Human Use, Lab Use Only.
Pyrvinium Iodide is an anthelmintic effective for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.
Pyrvinium Iodide is an anthelmintic effective for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.
Pyrvinium Iodide inhibits Wnt signaling downstream of β-catenin, and promotes Pygopus degradation.
Pyrvinium Iodide also is a potent inhibitor of HH signaling by reducing the stability of the Gli family of transcription factors.
