Catalog No.: PC-46115Not For Human Use, Lab Use Only.
Pyrvinium pamoate is an anthelmintic effective agent for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.
Pyrvinium pamoate is an anthelmintic effective agent for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.
Pyrvinium pamoate inhibits Wnt signaling downstream of β-catenin, and promotes Pygopus degradation.
Pyrvinium pamoate also is a potent inhibitor of HH signaling by reducing the stability of the Gli family of transcription factors.
