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Q308

Chemical Structure : Q308

CAS No.: 2700216-93-7

Q308 (Latent HIV-1 inhibitor)

Catalog No.: PC-38556Not For Human Use, Lab Use Only.

Q308 is a small molecule that silences the latent HIV-1 provirus by inhibiting Tat-mediated gene transcription and selectively downregulates the expression levels of the facilitated chromatin transcription (FACT) complex.

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Purity & Documentation Purity: 98.49% (HPLC) Select Batch:

Biological Activity

Q308 is a small molecule that silences the latent HIV-1 provirus by inhibiting Tat-mediated gene transcription and selectively downregulates the expression levels of the facilitated chromatin transcription (FACT) complex.
Q308 induced the preferential apoptosis in HIV-1 latently infected cells, Q308 may reduce the size of the viral reservoir.

Physicochemical Properties

M.Wt 301.302
Formula C15H15N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6,7,8-trimethoxy-2-(1H-pyrrol-2-yl)quinazolin-4(3H)-one

References

1. Zhou CL, et al. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0047021.

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