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Chemical Structure : QAPHA
Catalog No.: PC-22259Not For Human Use, Lab Use Only.
QAPHA is a dual function small molecule as both a tubulin polymerization and HDAC inhibitor, induces immunogenic cell death (ICD) through HDAC6 inhibition.
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QAPHA is a dual function small molecule as both a tubulin polymerization and HDAC inhibitor, induces immunogenic cell death (ICD) through HDAC6 inhibition.
QAPHA promotes CD4 but not CD8 T cells recruitment in TC-1 tumor infiltrate.
QAPHA antitumor effect do not synergize with anti-PD-1 immunotherapy.
QAPHA effectively inhibits HDAC6, leading to upregulation of HSP90, cytochrome C and caspases, as revealed by proteomic analysis.
QAPHA treatment leads to complete vaccination, elicits potent effector and durable memory antitumor immune responses against lung cancer.
QAPHA treatment promotes the infiltration of M1-polarized macrophages in treated mice, indicating the induction of a pro-inflammatory environment within the tumor.
QAPHA upregulates major histocompatibility complex class II (MHC-II) expression on TC-1 tumor cells both in vitro and in vivo.
| M.Wt | 374.40 | |
| Formula | C21H18N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sarah Ducellier, et al. J Immunother Cancer. 2024 Apr 11;12(4):e007588.
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