Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : QC-01-175
Catalog No.: PC-73296Not For Human Use, Lab Use Only.
QC-01-175 is a hetero-bifunctional molecule designed to engage both tau and Cereblon (CRBN) to trigger tau ubiquitination and proteasomal degradation (tau PROTAC).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
QC-01-175 is a hetero-bifunctional molecule designed to engage both tau and Cereblon (CRBN) to trigger tau ubiquitination and proteasomal degradation (tau PROTAC).
QC-01–175 effected clearance of tau in frontotemporal dementia (FTD) patient-derived neuronal cell models, with minimal effect on tau from neurons of healthy controls.
QC-01–175 also rescued stress vulnerability in FTD neurons, phenocopying CRISPR-mediated MAPT-knockout.
| M.Wt | 626.670 | |
| Formula | C33H34N6O7 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. M Catarina Silva, et al. Elife. 2019 Mar 25;8:e45457.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
