Catalog No.: PC-35843Not For Human Use, Lab Use Only.
QM31 (SVT016426, Apaf-1 inhibitor QM31) is a cytoprotective agent that inhibits the formation of the apoptosome (IC50=7.9 uM in vitro), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9.
QM31 (SVT016426, Apaf-1 inhibitor QM31) is a cytoprotective agent that inhibits the formation of the apoptosome (IC50=7.9 uM in vitro), and caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9.
QM31 (SVT016426) suppresses the Apaf-1-dependent intra-S-phase DNA damage checkpoint.
QM31 (SVT016426) can interfere with the two known functions of Apaf-1, namely apoptosome assembly/activation and intra-S-phase cell cycle arrest.
