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Chemical Structure : QM31
Catalog No.: PC-35843Not For Human Use, Lab Use Only.
QM31 (SVT016426, Apaf-1 inhibitor QM31) is a cytoprotective agent that inhibits the formation of the apoptosome (IC50=7.9 uM in vitro), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9.
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QM31 (SVT016426, Apaf-1 inhibitor QM31) is a cytoprotective agent that inhibits the formation of the apoptosome (IC50=7.9 uM in vitro), and caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9.
QM31 (SVT016426) suppresses the Apaf-1-dependent intra-S-phase DNA damage checkpoint.
QM31 (SVT016426) can interfere with the two known functions of Apaf-1, namely apoptosome assembly/activation and intra-S-phase cell cycle arrest.
| M.Wt | 768.557 | |
| Formula | C39H38Cl4N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mondragón L, et al. Apoptosis. 2009 Feb;14(2):182-90.
2. Mondragón L, et al. J Med Chem. 2008 Feb 14;51(3):521-9.
3. Malet G, et al. Cell Death Differ. 2006 Sep;13(9):1523-32.
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