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Chemical Structure : QN-302
CAS No.: 2546091-70-5
Catalog No.: PC-21822Not For Human Use, Lab Use Only.
QN-302 (SOP1812) is a tetrasubstituted naphthalene diimide compound binding to G-quadruplex (G4) DNA structures, shows high potency in pancreatic ductal adenocarcinoma (PDAC) cells.
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|---|---|---|---|
| 5 mg | $428 | In stock | |
| 10 mg | $728 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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QN-302 (SOP1812) is a tetrasubstituted naphthalene diimide compound binding to G-quadruplex (G4) DNA structures, shows high potency in pancreatic ductal adenocarcinoma (PDAC) cells.
QN-302 shows high affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively.
QN-302 has high anti-proliferative activity in pancreatic cancer cell lines and anti-tumor activity in several experimental models for the disease.
QN-302 also causes downregulation of the expression of the S100P gene and the S100P protein in cells and in vivo.
| M.Wt | 791.99 | |
| Formula | C45H57N7O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,7-bis(3-morpholinopropyl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)-9-(4-(pyrrolidin-1-ylmethyl)phenyl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone |
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1. Ahmed A Ahmed, et al. ACS Med Chem Lett. 2020 Jul 16;11(8):1634-1644.
2. Ahmed AA, et al. Molecules. 2023 Mar 7;28(6):2452.
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