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Chemical Structure : QNZ46
CAS No.: 1237744-13-6
Catalog No.: PC-73198Not For Human Use, Lab Use Only.
QNZ46 is a noncompetitive antagonist of NMDA receptor, selectively inhibits GluN2C/D-containing receptors with IC50 of 3.2/3.9 uM, repectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $428 | In stock | |
| 200 mg | $728 | In stock | |
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QNZ46 is a noncompetitive antagonist of NMDA receptor, selectively inhibits GluN2C/D-containing receptors with IC50 of 3.2/3.9 uM, repectively.
QNZ46 inhibits NMDA receptor function in a noncompetitive and voltage-independent manner by an unconventional mechanism that requires binding of glutamate to the GluN2 subunit, but not glycine binding to the GluN1 subunit.|
QNZ46 also prolongs deactivation of responses to the partial agonist NMDA in the continuous presence of glycine, prolongs receptor deactivation time.
| M.Wt | 443.42 | |
| Formula | C24H17N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-4-(6-methoxy-2-(3-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)-benzoic acid |
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1. Kasper B Hansen, et al. J Neurosci. 2011 Mar 9;31(10):3650-61.
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