QO IIR | COMT inhibitor | Probechem Biochemicals

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Chemical Structure : QO IIR

QO IIR (COMT inhibitor)

Catalog No.: PC-35901Not For Human Use, Lab Use Only.

QO IIR is a reversible, tight-binding inhibitor inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 320 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

QO IIR is a reversible, tight-binding inhibitor inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 320 nM.
QO IIR fully reverses the reserpine-induced catalepsy in vivo.
QO IIR demonstrates behavioural and neurochemical effects in reserpinized rats treated with LD/CD.

Physicochemical Properties

M.Wt	285.255
Formula	C15H11NO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3,4-Dihydroxy-2-nitrophenyl)-1-phenyl-2-propen-1-one

References

1. Rivas E, et al. Br J Pharmacol. 1999 Apr;126(7):1667-73.

2. Pérez RA, et al. Biochem Pharmacol. 1993 May 25;45(10):1973-81.

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