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Chemical Structure : QR-7909
Catalog No.: PC-22090Not For Human Use, Lab Use Only.
QR-7909 is a potent, specific and allosteric PI3Kα H1047R inhibitor with IC50 of 51 nM, 27-fold selective over WT PI3Kα in biochemical assays.
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QR-7909 is a potent, specific and allosteric PI3Kα H1047R inhibitor with IC50 of 51 nM, 27-fold selective over WT PI3Kα in biochemical assays.
QR-7909 exhibits cell IC50 of 113 nM for PI3KαH1047R (in T47D cell line), 55-fold for PI3KαH1047R over WT PI3Kα.
QR-7909 is specific to PI3Kα H1047R over other isoforms of PI3Ks.
| M.Wt | 490.95 | |
| Formula | C25H23ClN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huang X, et al. Structure. 2024 Mar 26:S0969-2126(24)00089-3.
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