QR-7909 | PI3Kα H1047R inhibitor | Probechem Biochemicals

Chemical Structure : QR-7909

QR-7909 (QR7909)

Catalog No.: PC-22090Not For Human Use, Lab Use Only.

QR-7909 is a potent, specific and allosteric PI3Kα H1047R inhibitor with IC50 of 51 nM, 27-fold selective over WT PI3Kα in biochemical assays.

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Biological Activity

QR-7909 is a potent, specific and allosteric PI3Kα H1047R inhibitor with IC50 of 51 nM, 27-fold selective over WT PI3Kα in biochemical assays.
QR-7909 exhibits cell IC50 of 113 nM for PI3KαH1047R (in T47D cell line), 55-fold for PI3KαH1047R over WT PI3Kα.
QR-7909 is specific to PI3Kα H1047R over other isoforms of PI3Ks.

Physicochemical Properties

M.Wt	490.95
Formula	C25H23ClN6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-chloro-3-((1-(2-(1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-3,6-dimethyl-4-oxo-3,4-dihydroquinazolin-8-yl)ethyl)amino)picolinic acid

References

1. Huang X, et al. Structure. 2024 Mar 26:S0969-2126(24)00089-3.

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QR-7909 (QR7909)

Biological Activity

Physicochemical Properties

References

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