QS-11 |CAS:944328-88-5 Probechem Biochemicals

Chemical Structure : QS-11

CAS No.: 944328-88-5

QS-11 (QS 11;QS11)

Catalog No.: PC-70264Not For Human Use, Lab Use Only.

QS-11 (QS11) is a small molecule inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) with Kd of 620 nM, synergizes the Wnt/beta-catenin signaling.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$258	In stock
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Biological Activity

QS-11 (QS11) is a small molecule inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) with Kd of 620 nM, synergizes the Wnt/beta-catenin signaling.
QS-11 synergizes with Wnt-3a in activating Wnt signaling through ARF activation (EC50=0.5 uM.
QS-11 increases levels of nuclear β-catenin and inhibits the migration of MDA-MB-231 cells with IC80 of 2.5 uM.

Physicochemical Properties

M.Wt	567.68
Formula	C36H33N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((9-([1,1'-biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino)-3-phenylpropan-1-ol

References

1. Zhang Q, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7444-8.

2. Singh MK, et al. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4838-42.

3. Ivanyuk D, et al. Cell Physiol Biochem. 2015;36(2):810-30.

QS-11 (QS 11;QS11)

Biological Activity

Physicochemical Properties

References

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