Quin C1 is a potent and selective FPR2 agonist with EC50 of 15 nM, induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells.
Quin C1 induces neutrophil chemotaxis and degranulation in vitro.
Quin C1 reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model.
Quin C1 exhibits anti-inflammatory property in a mouse model of bleomycin-induced lung injury.
