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Quinalizarin

Chemical Structure : Quinalizarin

CAS No.: 81-61-8

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Quinalizarin

Catalog No.: PC-62192Not For Human Use, Lab Use Only.

Quinalizarin is a potent, selective and cell-permeable inhibitor of CK2 with Ki of 58 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Quinalizarin is a potent, selective and cell-permeable inhibitor of CK2 with Ki of 58 nM.
    Quinalizarin shows selectivity over DYRK1a, PIMs, HIPK2, MNK1, ERK8 and PKD1.
    Quinalizarin inhibits endogenous CK2 and induces apoptosis more efficiently than Emodin in Jurkat cells.
    Quinalizarin reduces cell viability with emphasis on adenocarcinoma cells harboring EGFR sensitive mutation, suppresses migration, and accelerates apoptosis in different human lung cancer cell lines.

    Physicochemical Properties

    M.Wt 272.212
    Formula C14H8O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1,2,5,8-Tetrahydroxyanthracene-9,10-dione

    References

    1. Cozza G, et al. Biochem J. 2009 Jul 15;421(3):387-95.

    2. Zhou Y, et al. Indian J Cancer. 2015 Dec;52 Suppl 2:e119-24.

    3. Pan X, et al. Int J Oncol. 2016 Mar;48(3):1073-84.

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