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Chemical Structure : Quininib
Catalog No.: PC-60862Not For Human Use, Lab Use Only.
Quininib is a potent inhibitor of developmental angiogenesis in the zebrafish eye, and a cysteinyl leukotriene 1 and 2 receptor (CysLT1 and 2) antaognist with IC50 of 1.2 and 52 uM, respectively.
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Quininib is a potent inhibitor of developmental angiogenesis in the zebrafish eye, and a cysteinyl leukotriene 1 and 2 receptor (CysLT1 and 2) antaognist with IC50 of 1.2 and 52 uM, respectively.
Quininib demonstrates significant anti-angiogenic activity in human endothelial cell, murine aortic ring, and murine oxygen-induced retinopathy models of angiogenesis.
Quininib does not directly target VEGFRs, and inhibits angiogenesis in a range of cell and tissue systems.
| M.Wt | 247.3 | |
| Formula | C17H13NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Reynolds AL, et al. J Biol Chem. 2016 Apr 1;291(14):7242-55.
2. Murphy AG, et al. Sci Rep. 2016 Oct 14;6:34523.
3. Galvin O, et al. J Control Release. 2016 Jul 10;233:198-207.
4. Butler CT, et al. J Biol Chem. 2017 Mar 3;292(9):3552-3567.
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