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Chemical Structure : Quizartinib
CAS No.: 950769-58-1
Catalog No.: PC-43312Not For Human Use, Lab Use Only.
Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | Get quote |
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Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively.
Quizartinib (AC220) displays excellent kinase selectivity in a KinomeScan panel of 402 kinase binding assays, also potently inhibits PDGFRA, PDGFRB and RET.
Quizartinib (AC220) inhibits MV4-11 cell proliferarion with IC50 of 0.56 nM, demonstrates antitumor efficacy in the MV4-11 tumor xenograft model.
| M.Wt | 560.6672 | |
| Formula | C29H32N6O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Urea, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]- |
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1. Zarrinkar PP, et al. Blood. 2009 Oct 1;114(14):2984-92.
2. Chao Q, et al. J Med Chem. 2009 Dec 10;52(23):7808-16.
3. Pratz KW, et al. Blood. 2010 Feb 18;115(7):1425-32.
4. Gunawardane RN, et al. Mol Cancer Ther. 2013 Apr;12(4):438-47.
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