R-1479 is a potent, specific inhibitor of HCV NS5B polymerase and HCV replication (IC50=1.28 uM, replicon assay).
R-1479 shows no effect on cell viability or proliferation of HCV replicon or Huh-7 cells at >2 mM.
R-1479 inhibits RNA synthesis mediated by NS5B with IC50 of 320 nM, is the active form of Balapiravir (R-1479).
Physicochemical Properties
M.Wt
284.2288
Formula
C9H12N6O5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO
Chemical Name/SMILES
Cytidine, 4'-C-azido-
References
1. Smith DB, et al. Bioorg Med Chem Lett. 2007 May 1;17(9):2570-6.
2. Klumpp K, et al. J Biol Chem. 2006 Feb 17;281(7):3793-9.
3. Ali S, et al. Antimicrob Agents Chemother. 2008 Dec;52(12):4356-69.
