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Chemical Structure : R-7050
CAS No.: 303997-35-5
Catalog No.: PC-22719Not For Human Use, Lab Use Only.
R-7050 is a specific small molecule TNF-alpha receptor (TNFR) antagonist with EC50 of 0.63 uM for TNFα-induced ICAM-1 expression inhibition, shows greater selectivity toward TNFα.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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R-7050 is a specific small molecule TNF-alpha receptor (TNFR) antagonist with EC50 of 0.63 uM for TNFα-induced ICAM-1 expression inhibition, shows greater selectivity toward TNFα.
R-7050 displays 2- to 3-fold greater than EC50 for IL-1β-induced ICAM-1 expression (1.45 μM).
R-7050 inhibits phosphorylation of both the c-Jun N-terminal kinase (JNK) pathway (MKK4, JNKs, and ATF2) and p38 pathway (MKK3/6, p38, and MAPKAP2), inhibits interaction between TNFαRI, RIP1, and TRADD.
R-7050 blocks internalization of the TNFα ligand-receptor complex. exhibited inhibitory effects only in TNFα and LPA receptor systems, but not in IL-1βR, InsulinR, IGFR, or EGFR.
| M.Wt | 380.77 | |
| Formula | C16H8ClF3N4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline |
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1. King MD, et al. Neurosci Lett. 2013 May 10;542:92-6.
2. Gururaja TL, et al. Chem Biol. 2007 Oct;14(10):1105-18.
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