Catalog No.: PC-60376Not For Human Use, Lab Use Only.
R-IMPP ((R)-IMPP, PF-00932239) is a small molecule inhibitor of PCSK9 secretion (IC50=4.8 uM) that selectively binds to human 80S ribosome, but not E. coli, ribosomes.
R-IMPP ((R)-IMPP, PF-00932239) is a small molecule inhibitor of PCSK9 secretion (IC50=4.8 uM) that selectively binds to human 80S ribosome, but not E. coli, ribosomes.
R-IMPP causes transcript-dependent inhibition of PCSK9 translation, stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin.
