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Chemical Structure : R121919
CAS No.: 195055-03-9
Catalog No.: PC-21280Not For Human Use, Lab Use Only.
R121919 (NBI30775) is a highly potent, selective and nonpeptide antagonist of corticotropin-releasing factor 1 (CRF1) receptor with binding Ki of 3 nM (human and rat CRHR1), inhibits CRHR1-mediated signal transduction in transfected cells with IC50 of 60 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $178 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | $458 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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R121919 (NBI30775) is a highly potent, selective and nonpeptide antagonist of corticotropin-releasing factor 1 (CRF1) receptor with binding Ki of 3 nM (human and rat CRHR1), inhibits CRHR1-mediated signal transduction in transfected cells with IC50 of 60 nM.
R121919 has a 1000-fold lower affinity to 70 other central receptors tested.
R121919 dose-dependently suppresses CRH-induced ACTH secretion in rat corticotrope cells.
R121919 attenuates the behavioral and endocrine responses to stress in rats.
| M.Wt | 380.54 | |
| Formula | C22H32N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-[6-(dimethylamino)-4-methyl-pyrid-3-yl]-2,5-dimethyl-N,N-dipropyl-pyrazolo[2,3-a]pyrimidin-7-amine |
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1. Gutman DA, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):874-80.
2. Lancel M, et al. J Psychiatr Res. 2002 Jul-Aug;36(4):197-208.
3. M E Keck, et al. Eur J Neurosci. 2001 Jan;13(2):373-80.
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