Catalog No.: PC-21280Not For Human Use, Lab Use Only.
R121919 (NBI30775) is a highly potent, selective and nonpeptide antagonist of corticotropin-releasing factor 1 (CRF1) receptor with binding Ki of 3 nM (human and rat CRHR1), inhibits CRHR1-mediated signal transduction in transfected cells with IC50 of 60 nM.
R121919 (NBI30775) is a highly potent, selective and nonpeptide antagonist of corticotropin-releasing factor 1 (CRF1) receptor with binding Ki of 3 nM (human and rat CRHR1), inhibits CRHR1-mediated signal transduction in transfected cells with IC50 of 60 nM. R121919 has a 1000-fold lower affinity to 70 other central receptors tested. R121919 dose-dependently suppresses CRH-induced ACTH secretion in rat corticotrope cells. R121919 attenuates the behavioral and endocrine responses to stress in rats.
