Catalog No.: PC-28544Not For Human Use, Lab Use Only.
R1530 (R-1530) is a highly potent, orally active mitosis/angiogenesis inhibitor, inhibits angiogenesis-related receptor tyrosine kinases (KDR, FGFR) with IC50 of 10 nM and 28 nM, also inhibits PLK4 with IC50 of 7.06 nM.
R1530 (R-1530) is a highly potent, orally active mitosis/angiogenesis inhibitor, inhibits angiogenesis-related receptor tyrosine kinases (KDR, FGFR) with IC50 of 10 nM and 28 nM, also inhibits PLK4 with IC50 of 7.06 nM.
R1530 shows much weaker activities against CDK2 and CDK4.
R1530 inhibits the kinase activities of vascular endothelial growth factor receptor 2 (VGFr2), FGFR1, and PDGFR-β.
R1530 exhibits potent in vitro antiproliferative activity in various human tumor tissues including breast, colon, lung, prostate, melanoma, and oral epidermoid (IC50= 0.2-3.4 μM).
R1530 (25 or 50 mg/kg) produced significant tumor growth inhibition in MDA-MB-435 human tumor xenograft model.
