Chemical Structure : R4VP
CAS No.:
2839431-69-3
R4VP
(RNF4-VHL-Protac-like)
Catalog No.: PC-26979Not For Human Use, Lab Use Only.
R4VP (RNF4-VHL-Protac-like) is a PROTAC-like molecule that induces proteasomal degradation of RNF4, inhibits the proliferation and sphere formation (SFA) of A375R, a human melanoma cell line that is resistant to PLX4032, as well as SCC1 human squamous skin cancer cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
R4VP (RNF4-VHL-Protac-like) is a PROTAC-like molecule that induces proteasomal degradation of RNF4, inhibits the proliferation and sphere formation (SFA) of A375R, a human melanoma cell line that is resistant to PLX4032, as well as SCC1 human squamous skin cancer cells.
Physicochemical Properties
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M.Wt
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951.58
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Formula
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C51H59ClN6O8S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N1-(4-(4-(4-(N-benzyl-2-chloroacetamido)phenoxy)phenoxy)butyl)-N4-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)succinamide
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References
1. Oknin-Vaisman A, et al. Oncogene. 2026 Jun 5. doi: 10.1038/s41388-026-03829-2.
2. Carl C Ward, et al. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440.
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