Chemical Structure : R4VPL3-1
CAS No.:
R4VPL3-1
(R4VP L3-1)
Catalog No.: PC-26976Not For Human Use, Lab Use Only.
R4VPL3-1 is a PROTAC-like molecule that induces proteasomal degradation of RNF4, also induces the elimination of VHL in cancer cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
R4VPL3-1 is a PROTAC-like molecule that induces proteasomal degradation of RNF4, also induces the elimination of VHL in cancer cells.
R4VPL3-1 has significant anti-cancer activity towards human squamous cancer cells (SCC1), inhibiting proliferation and sphere formation (SFA) with IC50 of 0.3 uM.
R4VPL3-1 induces death of human skin and melanoma cancer cells, but does not affect MEFs and non-oncogenic cells.
R4VPL3-1 induces ferroptosis in A375R RTKi-resistant melanoma cells, co-inactivates anti-ferroptotic selanoproteins such as GPX4, along with the elimination of RNF4 and the anti-ferroptotic E3 ligase VHL.
Physicochemical Properties
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M.Wt
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1082.75
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Formula
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C57H72ClN7O10S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2R,4R)-1-((R)-2-(tert-butyl)-18-(4-(4-(2-chloro-N-(4-(dimethylamino)benzyl)acetamido)phenoxy)phenoxy)-4,13-dioxo-7,10-dioxa-3,14-diazaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
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References
1. Oknin-Vaisman A, et al. Oncogene. 2026 Jun 5. doi: 10.1038/s41388-026-03829-2.
2. Carl C Ward, et al. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440.
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