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Chemical Structure : RA-0002034
Catalog No.: PC-22094Not For Human Use, Lab Use Only.
RA-0002034 is a covalent, specific and cell-active chikungunya virus (CHIKV) nsP2 protease (nsP2pro) inhibitor with IC50 of 58 nM.
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RA-0002034 is a covalent, specific and cell-active chikungunya virus (CHIKV) nsP2 protease (nsP2pro) inhibitor with IC50 of 58 nM.
RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner.
RA-0002034 shows no significant off-target reactivity against a panel of cysteine proteases.
RA-0002034 effectively inhibits viral replication of both CHIKV and related alphaviruses in cellular models of alphavirus infection.
RA-0002034 inhibits CHIKV replication with an EC50 of 11 nM and VEEV replication with an EC50 of 320 nM, suggesting activity across multiple alphaviruses.
| M.Wt | 349.41 | |
| Formula | C16H19N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Eric M Merten, et al. bioRxiv [Preprint]. 2024 Mar 22:2024.03.22.586341.
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