Chemical Structure : RAC1 inhibitor A41
CAS No.:
694515-65-6
RAC1 inhibitor A41
Catalog No.: PC-24945Not For Human Use, Lab Use Only.
RAC1 inhibitor A41 is a potent, specific and reversible inhibitor of RAC proteins, competes with guanine nucleotide binding, inhibits RAC1-dependent membrane ruffle formation with IC50 of 2.5 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RAC1 inhibitor A41 is a potent, specific and reversible inhibitor of RAC proteins, competes with guanine nucleotide binding, inhibits RAC1-dependent membrane ruffle formation with IC50 of 2.5 nM.
A41 (10 uM) blocks RAC1 activation in EGF-stimulated NIH/3T3 fibroblasts.
A41 is not RAC-GEF dependent.
A41 (10 uM) reduced TRIO-induced activation of RAC2, which is closely related to RAC1, but had no effect on TRIO-induced RHOG activation.
A41 directly interacts with RAC1 (SPR KD = 30 nM), shows no affinity for RHOA and CDC42.
A41 inhibits RAC1 activity and oncogenic properties of TNBC cell line, decreases growth and invasiveness of TNBC cells in vitro.
A41 (25 mg/kg/day, i.p.) prevents metastasis in a mouse model of TNBC.
Physicochemical Properties
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M.Wt
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486.60
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Formula
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C24H26N2O5S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-(N-(2,5-dimethoxyphenyl)sulfamoyl)phenyl)-3-(p-tolylthio)propanamide
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References
1. Dilasser F, et al. Cell Rep Med. 2025 Jun 28:102233.
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