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RAD51-IN-17

Chemical Structure : RAD51-IN-17

CAS No.: 2101739-18-6

RAD51-IN-17

Catalog No.: PC-62839Not For Human Use, Lab Use Only.

RAD51-IN-17 is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines.

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Biological Activity

RAD51-IN-17 is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines.
RAD51-IN-17 also sensitizes aggressive metastatic TNBC to DNA damage induced by irradiation.
RAD51-IN-17 is a valuable research tool for developing combination therapies to overcome RAD51 driven resistance and relapse in a variety of cancers.

Physicochemical Properties

M.Wt 373.84
Formula C22H16ClN3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-3-(4-chlorobenzyl)-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one

References

1. Ward A, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100.

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