RANKL inhibitor 19u

Chemical Structure : RANKL inhibitor 19u

Catalog No.: PC-25333Not For Human Use, Lab Use Only.

RANKL inhibitor 19u is a potent small molecule inhibitor of RANKL-RANK protein interaction with BLI KD of 7.6 uM (RANKL), inhibits RANKL-induced TRAP activity in RAW264.7 cells with IC50 of 0.07 uM.

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Biological Activity

RANKL inhibitor 19u is a potent small molecule inhibitor of RANKL-RANK protein interaction with BLI KD of 7.6 uM (RANKL), inhibits RANKL-induced TRAP activity in RAW264.7 cells with IC50 of 0.07 uM.
RANKL inhibitor 19u inhibited RANKL-induced osteoclastogenesis without affecting osteoblast differentiation.
RANKL inhibitor 19u reduced ROS production during osteoclastogenesis and inhibited RANKL-induced bone resorption.
RANKL inhibitor 19u disrupted RANKL-induced osteoclast differentiation by inhibiting MARK/NF-κB signaling pathways and preventing the subsequent induction of the expression of the key osteoclastogenesis regulator NFATc1 and its target genes.
RANKL inhibitor 19u increased bone mass in a dexamethasone-induced osteoporosis model in zebrafish, decreased bone loss in the OVX model.

Physicochemical Properties

M.Wt	621.91
Formula	C40H55N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((2R,4aS,6aS,6bS,16aS)-2,4a,6a,6b,9,16a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,16,16a,16b-dodecahydrochryseno[1,2-g]quinoxalin-2-yl)(4-(piperazin-1-yl)piperidin-1-yl)methanone

References

1. Xuefeng Fu, et al. J Med Chem. 2025 Aug 10. doi: 10.1021/acs.jmedchem.5c01380.