RANKL inhibitor T8

Chemical Structure : RANKL inhibitor T8

Catalog No.: PC-25329Not For Human Use, Lab Use Only.

RANKL inhibitor T8 is a nonpeptidic small molecular inhibitor targeting RANKL and RANK protein interaction, directly binds to RANKL with KD of 6.3 uM.

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Biological Activity

RANKL inhibitor T8 is a nonpeptidic small molecular inhibitor targeting RANKL and RANK protein interaction, directly binds to RANKL with KD of 6.3 uM.

Physicochemical Properties

M.Wt	623.07
Formula	C26H22ClF3N6O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-((2-(4-chlorobenzoyl)hydrazineyl)(pyrrolidin-1-yl)methylene)-4-(5-(thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

References

1. Melagraki G, et al. PLoS Comput Biol. 2017 Apr 20;13(4):e1005372.

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