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RB-101

Chemical Structure : RB-101

CAS No.: 135949-60-9

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RB-101 (RB101)

Catalog No.: PC-63049Not For Human Use, Lab Use Only.

RB-101 is an mixed enkephalinase inhibitor that inhibits Aminopeptidase N and Neutral Endopeptidase with IC50 of 11 nM and 2 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RB-101 is an mixed enkephalinase inhibitor that inhibits Aminopeptidase N and Neutral Endopeptidase with IC50 of 11 nM and 2 nM, respectively; induces potent analgesic responses in mice and rats.

Physicochemical Properties

M.Wt 582.84
Formula C31H38N2O3S3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Phenylmethyl (2S)-2-[(2-([(2S)-2-amino-4-methylsulfanylbutyl]disulfanylmethyl)-3-phenylpropanoyl)amino]-3-phenylpropanoate

References

1. Ruiz-Gayo M, et al. Brain Res. 1992 Feb 7;571(2):306-12.

2. Noble F, et al. J Pharmacol Exp Ther. 1992 Apr;261(1):181-90.

3. Baamonde A, et al. Eur J Pharmacol. 1992 Jun 5;216(2):157-66.

4. Fournié-Zaluski MC, et al. J Med Chem. 1992 Jun 26;35(13):2473-81.

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