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RB-101

Chemical Structure : RB-101

CAS No.: 135949-60-9

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RB-101 (RB101)

Catalog No.: PC-63049Not For Human Use, Lab Use Only.

RB-101 (RB101) is an mixed enkephalinase inhibitor that inhibits Aminopeptidase N and neutral Endopeptidase with IC50 of 11 nM and 2 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RB-101 (RB101) is an mixed enkephalinase inhibitor that inhibits Aminopeptidase N and neutral Endopeptidase with IC50 of 11 nM and 2 nM, respectively.
    RB-101 induces potent analgesic responses in mice and rats.

    Physicochemical Properties

    M.Wt 582.84
    Formula C31H38N2O3S3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Phenylmethyl (2S)-2-[(2-([(2S)-2-amino-4-methylsulfanylbutyl]disulfanylmethyl)-3-phenylpropanoyl)amino]-3-phenylpropanoate

    References

    1. Ruiz-Gayo M, et al. Brain Res. 1992 Feb 7;571(2):306-12.

    2. Noble F, et al. J Pharmacol Exp Ther. 1992 Apr;261(1):181-90.

    3. Baamonde A, et al. Eur J Pharmacol. 1992 Jun 5;216(2):157-66.

    4. Fournié-Zaluski MC, et al. J Med Chem. 1992 Jun 26;35(13):2473-81.

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