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RBBP7-TP4

Chemical Structure : RBBP7-TP4

CAS No.:

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RBBP7-TP4 (Histone H4 (25-36))

Catalog No.: PC-28261Not For Human Use, Lab Use Only.

RBBP7-TP4 is a specific histone-binding protein RBBP7-targeting peptide with SPR KD of 0.204 uM, disrupts the RBBP7-histone H4 interaction, reduces histone H4 acetylation and downregulates DNMT1.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RBBP7-TP4 is a specific histone-binding protein RBBP7-targeting peptide with SPR KD of 0.204 uM, disrupts the RBBP7-histone H4 interaction, reduces histone H4 acetylation and downregulates DNMT1.
RBBP7-TP4 inhibits the viability of JHH-7 cells.
inhibit the interaction between RBBP7 and histone H4.
RBBP7-TP4 exhibits potent anti-tumor activity in both cellular and xenograft mouse models of hepatocellular carcinoma (HCC).
RBBP7-TP4 synergizes with HDAC inhibitors to enhance epigenetic efficacy in HCC models.

Physicochemical Properties

M.Wt 1366.64
Formula C59H107N21O16
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Asn-Ile-Gln-Gly-Ile-Thr-Lys-Pro-Ala-Ile-Arg-Arg

References

1. Zan Gao, et al. Cell Chem Biol. 2026 Sep 15:S2451-9456(26)00322-3.

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