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RC-752

Chemical Structure : RC-752

CAS No.: 1808994-61-7

RC-752 (RC752, (R/S)-RC-752)

Catalog No.: PC-21055Not For Human Use, Lab Use Only.

RC-752 is a potent, seletive sigma-1 receptor (S1R) antagonist with Ki of 6.2 nM, 50-fold selective over S2R, shows antinociceptive activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RC-752 is a potent, seletive sigma-1 receptor (S1R) antagonist with Ki of 6.2 nM, 50-fold selective over S2R, shows antinociceptive activity.
RC-752 shows no cytotoxic effect in two normal human cell lines or in an in vivo zebrafish model.
RC-752 effectively alleviated pain the formalin test and the spinal nerve ligation model of neuropathic pain (NP).

Physicochemical Properties

M.Wt 309.45
Formula C21H27NO
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

OCC(CCN1CCCCC1)C(C=C2)=CC=C2C3=CC=CC=C3

References

1. Giacomo Rossino, et al. Pharmaceuticals (Basel)
. 2023 Jul 5;16(7):962.

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