Chemical Structure : REP8839
CAS No.:
757942-43-1
REP8839
(Bederocin)
Catalog No.: PC-23524Not For Human Use, Lab Use Only.
REP8839 (Bederocin) is a potent inhibitor of S. aureus methionyl-tRNA synthetase (MetRS) with IC50 of <1.9 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
REP8839 (Bederocin) is a potent inhibitor of S. aureus methionyl-tRNA synthetase (MetRS) with IC50 of <1.9 nM.
REP8839 also inhibits two gram-negative homologs of S. aureus MetS, H. influenzae MetG and E. coli MetG, albeit with at least 13-fold- and 160-fold-lower potency, respectively.
REP8839 exerts its antibacterial activity through specific inhibition of MetS in S. aureus.
REP8839 demonstrated a dose-dependent inhibition of protein synthesis and RNA synthesis in S. pneumoniae R6, but only protein synthesis was affected in an isogenic rel mutant deficient in the stringent response.
Physicochemical Properties
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M.Wt
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450.37
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Formula
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C20H21BrFN3OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4(1H)-Quinolinone, 2-[[3-[[[4-bromo-5-(1-fluoroethenyl)-3-methyl-2-thienyl]methyl]amino]propyl]amino]-
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References
1. Critchley IA, et al. Antimicrob Agents Chemother. 2005 Oct;49(10):4247-52.
2. Ochsner UA, et al. Antimicrob Agents Chemother. 2005 Oct;49(10):4253-62.
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