Catalog No.: PC-23406Not For Human Use, Lab Use Only.
RF26 (Compound d12) is a highly potent and selective PDE5 inhibitor with IC50 of 1 nM, three times more potent than sildenafil and more selective with a selectivity index of >10,000-fold against all other PDE isozymes.
RF26 (Compound d12) is a highly potent and selective PDE5 inhibitor with IC50 of 1 nM, three times more potent than sildenafil and more selective with a selectivity index of >10,000-fold against all other PDE isozymes.
RF26 has a mechanism of enzyme inhibition distinct from sildenafil.
RF26 is active against PDE5 catalytic domain (IC50=1 nM, full-length PDE5), but not PDE5 catalytic domain even at 1 uM.
RF26 inhibits PDE5 and increase the intracellular cGMP in live HEK-293 cells transfected to stably express a cGMP biosensor (EC50=6.7 uM).
RF26 improves memory impairment and ameliorates tau aggregation and neuroinflammation in the P301S tauopathy mouse model of Alzheimer's disease.
