Chemical Structure : RF26
CAS No.:
2699052-46-3
RF26
(Compound d12)
Catalog No.: PC-23406Not For Human Use, Lab Use Only.
RF26 (Compound d12) is a highly potent and selective PDE5 inhibitor with IC50 of 1 nM, three times more potent than sildenafil and more selective with a selectivity index of >10,000-fold against all other PDE isozymes.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RF26 (Compound d12) is a highly potent and selective PDE5 inhibitor with IC50 of 1 nM, three times more potent than sildenafil and more selective with a selectivity index of >10,000-fold against all other PDE isozymes.
RF26 has a mechanism of enzyme inhibition distinct from sildenafil.
RF26 is active against PDE5 catalytic domain (IC50=1 nM, full-length PDE5), but not PDE5 catalytic domain even at 1 uM.
RF26 inhibits PDE5 and increase the intracellular cGMP in live HEK-293 cells transfected to stably express a cGMP biosensor (EC50=6.7 uM).
RF26 improves memory impairment and ameliorates tau aggregation and neuroinflammation in the P301S tauopathy mouse model of Alzheimer's disease.
Physicochemical Properties
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M.Wt
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470.56
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Formula
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C26H32F2N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(4-(3-(tert-Butyl)-5-(3,5-difluoro-4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone
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References
1. Sigler S, et al. Anticancer Agents Med Chem. 2024 Sep 2. doi: 10.2174/0118715206318802240821114353.
2. El-Desouky S, et al. Exp Neurol. 2024 Nov 14:115058.
3. Abdel-Halim M, et al. J Med Chem. 2021 Apr 22;64(8):4462-4477.
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