Chemical Structure : RG0216
CAS No.:
1670274-46-0
RG0216
(RG-0216)
Catalog No.: PC-23801Not For Human Use, Lab Use Only.
RG0216 is a potent, selective and reversible monoamine oxidase (MAO-B) inhibitor, >260-fold selectivity over MAO-A.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RG0216 is a potent, selective and reversible monoamine oxidase (MAO-B) inhibitor, >260-fold selectivity over MAO-A.
RG0216 (20 and 100 µM) fully inhibited MAO-B activity in cell lysate preparations up to 8 μg/ml (log10 0.9).
RG0216 reduces LPS-induced IL-6 and IL-1β protein secretion in SiHa cells, with no significant effect on baseline IL-6 and IL-1β gene expression.
RG0216 downregulates cAMP-mediated induction of IL-6 and IL-1β gene and protein expression.
RG0216 reduced PKA/EPAC-induced IL-1β gene expression, also decreased PKA activation-induced effect on IL-6 protein expression.
Physicochemical Properties
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M.Wt
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463.19
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Formula
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C19H22BrCl2NO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-N-(1-(4-((4-bromo-3-chlorobenzyl)oxy)phenyl)propan-2-yl)-N-methylglycine hydrochloride
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References
1. Putnins EE, et al. Front Pharmacol. 2021 Nov 17;12:741460.
2. Ostadkarampour M, et al. Eur Rev Med Pharmacol Sci. 2024 Dec;28(24):4681-4690.
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