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RG13022

Chemical Structure : RG13022

CAS No.: 136831-48-6

RG13022 (Tyrphostin RG13022, RG-13022)

Catalog No.: PC-42386Not For Human Use, Lab Use Only.

RG13022 is a potent EGFR inhibitor that inhibits EGFR autophosphorylation with IC50 of 5 uM in cell-free assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RG13022 is a potent EGFR inhibitor that inhibits EGFR autophosphorylation with IC50 of 5 uM in cell-free assays.
RG13022 suppresses not only EGF-stimulated cancer cell proliferation in vitro but also tumor growth in nude mice.
RG13022 inhibits cell proliferation of gastric cancer cell lines.

Physicochemical Properties

M.Wt 266.29456
Formula C16H14N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 10 mM

Chemical Name/SMILES

3-Pyridineacetonitrile, α-[(3,4-dimethoxyphenyl)methylene]-

References

1. Yoneda T, et al. Cancer Res. 1991 Aug 15;51(16):4430-5.

2. McLeod HL, et al. Br J Cancer. 1996 Dec;74(11):1714-8.

3. McLaughlin M, et al. Int J Oncol. 1996 Mar;8(3):589-96.

4. Xian W, et al. Cell Growth Differ. 1995 Nov;6(11):1447-55.

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