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Chemical Structure : RGFP966
CAS No.: 1357389-11-7
Catalog No.: PC-20237Not For Human Use, Lab Use Only.
RGFP966 (RGFP 966) is a potent, specific HDAC3 inhibitor with IC50 of 0.08 uM, without effective inhibition of any other HDACs at 15 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | $358 | In stock |
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RGFP966 (RGFP 966) is a potent, specific HDAC3 inhibitor with IC50 of 0.08 uM, without effective inhibition of any other HDACs at 15 uM.
RGFP966 facilitates extinction in mice in a manner resistant to reinstatement.
RGFP966 enhances the rate and persistence of extinction of cocaine-CPP. RGFP966 enhances acquisition/consolidation of memory.
RGFP966 promotes histone acetylation and gene expression during extinction consolidation.
RGFP966 alters the regulation of c-fos via HDAC3 and its acetylation during the consolidation of extinction.
RGFP966 causes significant reduction in DNA replication fork velocity, inhibits cell growth in CTCL cell lines with increased apoptosis.
| M.Wt | 362.41 | |
| Formula | C21H19FN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide |
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1. Malvaez M, et al. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2647-52.
2. Wells CE, et al. PLoS One. 2013 Jul 22;8(7):e68915.
3. Bieszczad KM, et al. J Neurosci. 2015 Sep 23;35(38):13124-32.
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